Weight loss plateau: 3 months on AOD-9604
I’ve been on a strict AOD-9604 protocol for 12 weeks now, combined with a caloric deficit and resistance training. The first two months were great—I dropped about 12 pounds and my body composition definitely shifted. However, for the last two weeks, the scale hasn't budged. I’m wondering if I’ve hit a metabolic adaptation or if I should look into adjusting my dosage. I’m currently at 300mcg daily. Has anyone else experienced a stall around the 3-month mark? I’m considering asking my doctor about cycling off for a few weeks or potentially adding something else to the stack, but I want to be careful. Any advice from those who have run longer AOD cycles?
Hitting a plateau at the 12-week mark is quite common with AOD-9604, as the body often initiates homeostatic adjustments to preserve energy during prolonged caloric restriction. AOD-9604 functions primarily by stimulating lipolysis and inhibiting lipogenesis via the C-terminal fragment of human growth hormone, but it does not directly modulate thyroid hormones or hunger-regulating ghrelin/leptin pathways. When weight loss stalls, it often points to metabolic adaptation where your TDEE has lowered to match your intake. Before considering a dosage adjustment—which should always be discussed with your physician—evaluate if you have adjusted your macros to account for your new, lighter body weight. Many in our community find that implementing a 'diet break' or cycling off the peptide for 2-4 weeks helps reset hormonal signaling and sensitize receptors. Ensure your resistance training intensity remains high to maintain metabolic rate, but consider checking your NEAT levels as well. Since this isn't medical advice, definitely consult your provider, but focus on the 'lifestyle reset' phase first to see if you can break through naturally.