AOD-9604 and weight loss: Is the plateau real?
I’ve been on AOD-9604 (300mcg SubQ daily) for about 10 weeks now to help with stubborn fat loss. The first 6 weeks were incredible—I dropped about 8 pounds and felt like my metabolism was finally firing on all cylinders. However, for the last two weeks, the scale hasn't budged. I’m still hitting my macros and keeping up with my lifting routine. I’ve heard some people suggest cycling off for a few weeks before starting another round, but I’m hesitant to lose the momentum. Given the recent FDA Category 1 shift, my doctor is more open to discussing long-term strategies, but I wanted to see what the community experience is. Should I consider adding something else to the stack, or is a plateau just a natural part of the AOD-9604 process? Any advice from those who have run longer cycles would be appreciated.
It is very common to experience a plateau around the 8-10 week mark with AOD-9604. As a modified fragment of the C-terminus of HGH, AOD-9604 primarily works by stimulating lipolysis and inhibiting lipogenesis. After several weeks of constant administration, some users report a down-regulation in the sensitivity of the targeted beta-3 adrenergic receptors. Taking a 2-4 week 'washout' period is a standard strategy in the community to allow these receptors to reset and avoid systemic adaptation. Many find that once they resume, the lipolytic response returns to baseline. Also, ensure your caloric deficit is still adjusted to your new, lower body weight, as your BMR has likely shifted downward after losing those 8 pounds. While the FDA classification changes have certainly made supplies more difficult to source, focusing on that reset period often proves more beneficial for long-term progress than pushing through a stall. Please consult with a clinical professional, as this is just shared experience.