Stacking CJC-1295/Ipamorelin with MK-677: Sleep quality and hunger management
I’ve been running a stack of CJC-1295/Ipamorelin (100mcg/100mcg) before bed and 10mg of MK-677 in the morning for about 6 weeks now. The sleep quality is incredible—I’m hitting deep sleep cycles I haven't seen in years according to my Oura ring. However, the hunger from the MK-677 is becoming a bit of a challenge to manage. I’m trying to lean out, but the cravings are intense. Does anyone have tips for mitigating the ghrelin spike while still getting the benefits of the growth hormone pulse? Also, I’m keeping a close eye on my fasting glucose levels since starting this. My last bloodwork showed a slight uptick, so I’ve added berberine to my morning routine. Has anyone else had to adjust their diet or supplements to keep their blood sugar in check while on this specific stack?
It is great to hear you are seeing the restorative sleep benefits from the CJC/Ipa combo, as that is a common highlight for many users. The hunger you are experiencing is the classic side effect of MK-677 acting as a potent ghrelin mimetic. Because MK-677 increases serum levels of ghrelin, the hunger response is physiological rather than purely psychological. To manage this, many users transition their dose to the evening, just before bed. This often helps users 'sleep through' the worst of the ghrelin spike. Additionally, increasing dietary fiber and focusing on high-volume, low-calorie foods—like cruciferous vegetables—can help mechanically stretch the stomach and signal satiety. Some community members also find that supplementing with Berberine can help manage the secondary effect of improved insulin sensitivity, which sometimes accompanies the MK-677 hunger cycle. Remember, this is anecdotal community discussion, not medical advice, so monitor your fasting blood glucose regularly, as MK-677 can impact glycemic control in some individuals.