CJC-1295/Ipamorelin + MK-677: 8-week progress report and bloodwork
I just hit the 8-week mark on my current stack: 100mcg CJC-1295/Ipamorelin (no DAC) nightly, plus 12.5mg MK-677. My goal was body recomposition and better sleep. The results have been pretty solid—my HRV has improved from 35ms to 52ms, and my deep sleep scores on my wearable are consistently higher. I just got my bloodwork back, and my IGF-1 levels jumped from 180 to 265 ng/mL. My fasting glucose is up slightly (from 88 to 98 mg/dL), so I am definitely going to keep a close eye on my carb intake and maybe add some berberine. Has anyone else experienced this kind of glucose shift with MK-677, and how are you managing it?
Solid progress report. Seeing that IGF-1 increase to 265 ng/mL is expected with the synergy between your GHRH and GHRP, as they stimulate pulsatile growth hormone secretion via the pituitary. It is great that your HRV improved significantly, as that often correlates with improved recovery and hormonal signaling. Regarding your fasting glucose rising to 98 mg/dL, you are right to be vigilant. MK-677, being a potent ghrelin mimetic, is notorious for inducing insulin resistance by increasing growth hormone and IGF-1, which can antagonize insulin action. Many in the community find that adding Berberine or GDA (Glucose Disposal Agents) before carb-heavy meals helps manage this. Since you are at the 8-week mark, consider if you need a period of cycling off or lowering the MK-677 dose to keep your HOMA-IR in check. Always consult with your physician regarding your lab trends. Keep up the detailed tracking.