Bloodwork check: 3 months on CJC-1295/Ipamorelin
Just got my latest labs back after 12 weeks on a CJC-1295/Ipamorelin protocol (100mcg/100mcg nightly). My IGF-1 levels moved from 145 ng/mL to 210 ng/mL, which is a solid jump. More importantly, my sleep quality has improved drastically—my Oura ring shows my deep sleep increased from an average of 45 minutes to 1 hour and 20 minutes per night. I’ve also noticed my recovery time after heavy lifting sessions is much faster. My doctor is happy with the results, but I’m curious if anyone else has seen their fasting glucose fluctuate while on this stack? Mine ticked up slightly, though it’s still well within the normal range. Just want to make sure I’m staying ahead of any potential metabolic side effects.
Those are excellent markers, especially the shift in IGF-1 levels. Seeing a move from 145 to 210 ng/mL suggests that your endogenous HGH secretion is being stimulated effectively. The mechanism here is twofold: Ipamorelin acts as a selective growth hormone secretagogue by binding to the ghrelin receptor, while CJC-1295 (without DAC) mimics GHRH to amplify the pulse amplitude. That synergy is almost certainly responsible for the enhanced restorative sleep you are tracking; increased HGH pulsatility is well-documented to improve slow-wave deep sleep cycles. Since you are hitting the 12-week mark, many users typically consider a short 'reset' period to prevent receptor desensitization or downregulation, though with your specific dosage, some choose to continue. Have you discussed a potential maintenance phase or a short break with your doctor to monitor how your natural baseline holds up? Great work tracking this with actual Oura data rather than just feeling; it makes the protocol much more objective.